Agilent 6460 LCMSMS QQQ
Includes:
LCMS K6460 QQQ System
1290 TCC
6400 Series QQQ LC/MS Sys.Tracking ModuL
1260 HiP Autosampler
1260 Binary Pump
1260 HiP Degasser
1 Installation and training - optional $6000
The Agilent 6460 Triple Quadrupole LC/MS delivers superior sensitivity for trace level analysis with performance specifications in Signal-to-Noise ratio (S/N) and Instrument Detection Limit (IDL). IDL is a rigorous, statistically based metric that indicates practical sensitivity performance of your quantitative assays.
The Agilent 6460 Triple Quadrupole LC/MS achieves sensitivity and resolution specifications with autotune. Data Sheet Parameter Measure Specification MRM sensitivity Signal-to-Noise ratio (S/N) ESI positive 1 pg of reserpine injected on column, quantifying on the transition m/z 609 to 195 S/N > 30,000:1 Noise 1 × RMS MRM sensitivity Signal-to-Noise ratio (S/N) ESI negative 1 pg of chloramphenicol injected on column, quantifying on the transition m/z 321 to 152 S/N > 10,000:1 Noise 1 × RMS MRM sensitivity Instrument Detection Limit (IDL) ESI positive 20 fg of reserpine injected on column, quantifying on the transition m/z 609 to 195 IDL < 12.5 fg MRM sensitivity Instrument Detection Limit (IDL) ESI negative 20 fg of chloramphenicol injected on column, quantifying on the transition m/z 321 to 152 IDL < 12.5 fg Mass range m/z 5 – 3,000 Polarity switching 30 ms Mass resolution (autotune) Mass resolution (manual tune) Full width at half maximum Full width at half maximum 0.7 Da 0.5 Da Mass accuracy 0.1 Da from 5 – 1,000 m/z 0.01% from 1,000 – 2,000 m/z 0.02% from 2,000 – 3,000 m/z Mass stability < 0.1 Da in 24 h Dynamic range > 6.0 × 106 Scan modes MS scan, MS/MS product ion scan, MRM, MS/MS neutral loss/gain scan and precursor ion scan, SIM Maximum scan rate 12,500 Da/s Minimum MRM dwell time 1 ms MRM transitions 450 per time segment > 40,000 ion transactions per method Dynamic MRM transitions 4,000 ion transitions per method Triggered MRM transitions Up to 10 MRM transitions (primary and secondary) for library search and compound confirmation Collision cell ion clearance < 1 ms www.agilent.com/chem/qqq Agilent Technologies shall not be liable for errors contained herein or for incidental or consequential damages in connection with the furnishing, performance, or use of this material.
Information, descriptions, and specifications in this publication are subject to change without notice. © Agilent Technologies, Inc. 2014 Published in the U.S.A. September 21, 2014 5989-9905EN General system specifications Ordering information G6460CA: 6460 Triple Quadrupole LC/MS System Includes the 6460 Triple Quadrupole Mass Spectrometer, MassHunter Workstation Software with both compliance and method optimization software, a PC, a monitor and printer, and service installation of the system Parameter Specification Single point of control Single-point data system method capability with full control of Agilent 1200 Series HPLC systems and 6460C Triple Quadrupole LC/MS System Time programming • Polarity change in time segment • Scan and SIM or MRM (plus other modes of data collection) • Dynamic and triggered MRM aligns MRMs with compound retention time • Solvent divert through calibrant delivery system valve Wide range of ionization sources • Electrospray (ESI) • Nanospray with HPLC-Chip Cube MS interface • APCI source (Atmospheric Pressure Chemical Ionization) • Multimode source (simultaneous ESI and APCI) • APPI source (Atmospheric Pressure Photo Ionization) Autotune Automated optimization of ion optics and mass axis calibration in positive and negative ion modes using a proprietary tune solution Solvent declustering Countercurrent gas Detector High-energy conversion dynode and high-gain electron multiplier horn Vacuum system Two turbomolecular pumps with one mechanical pump
