Quantify with outstanding accuracy using the Thermo Scientific TSQ Quantum triple quadrupole mass spectrometer. Achieve outstanding sensitivity and specificity without sacrificing versatility. The TSQ Quantum Ultra system is available with optional extended mass range (EMR), accurate mass (AM), and high-field asymmetric waveform ion mobility spectrometry (FAIMS) capabilities to meet the demands of the widest range of applications.
Excellent Quantitative Performance
- Thermo Scientific™ Ion Max™ Ion Source with HESI-II probe and Thermo Scientific™ HyperQuad™ Mass Filter reduce noise and increase sensitivity, enhancing quantitative performanceQuantitation-enhanced data-dependent MS/MS (QED-MS/MS) provides simultaneous compound confirmation and quantificationHigh-resolution selected reaction monitoring (H-SRM) enables quantification of many compounds in a single runZero-cross-talk collision cell eliminates false positives
Easy, Robust, and Reliable
- Self-cleaning Ion Max source and automatic source recognition simplify operation and increase reliability
Extended Mass Range for Better Large-Molecule Analysis
- Optional 3000 Da mass range, which also includes higher mass resolution and higher-resolution precursor selection, improves analysis of peptides, polysaccharides, intact proteins, and oligo nucleotides
Enhanced Mass Accuracy for Greater Confidence
- Optional accurate mass (AM) capability provides a higher degree of confidence in compound identification
Electrospray (HESI) at High Resolution 0.2 Da FWHM A 5 μL injection of a 200 fg/μL reserpine solution on a Hypersil GOLD aQ 20 X 2.1 mm 1.9 μm particle packed column at a flow rate of 300 μL/min 30:70:0.02 water/methanol/formic acid will produce a minimum signal-to-noise ratio of 3000:1 for the transition of the protonated molecule at m/z 609.3 to the fragment ion at m/z 195.1 when operated in selected reaction monitoring mode (SRM) with Q1 and Q3 resolution set to 0.2 and 0.7 Da FWHM respectively.
Atmospheric Pressure Chemical Ionization (APCI) and Atmospheric Pressure Photoionization (APPI) at High Resolution 0.2 Da FWHM A 5 μL injection of a 200 fg/μL reserpine solution on a Hypersil GOLD aQ 20 X 2.1 mm 1.9 μm particle packed column at a flow rate of 300 μL/min 30:70:0.02 water/methanol/formic acid will produce a minimum signal-to-noise ratio of 300:1 for the transition of the protonated molecule at m/z 609.3 to the fragment ion at m/z 195.1 when operated in selected reaction monitoring mode (SRM) with Q1 and Q3 resolution set to 0.2 and 0.7 Da FWHM respectively.
Mass Accuracy– TSQ Quantum Ultra AM
Infusion of a mixture of polyethylene glycols (PEGs) of average molecular weights 200, 400, 600, and 1000 at 50 pmoles/μL produces 27 ammoniated PEG ions from 124 to 1268 Da. Accurate mass data is generated on each of the 25 ions from 168 to 1224 Da using the neighboring peaks as internal lock masses. The mass of each ion is determined from the average of up to 100 scans and the error between the expected mass and the measured mass is expressed in mmu and ppm. The root mean square (RMS) average is computed from the errors of the 25 individual ions. The RMS error will be less than or equal to 5 ppm.
10–1500 Da (TSQ Quantum Ultra/Ultra AM)
10–3000 Da (TSQ Quantum Ultra EMR)
7500 (FWHM) at m/z 508 of polytyrosine Resolution is continuously adjustable to better than 0.1 Da peak width (FWHM) across the entire mass range.
The laboratory room temperature must be maintained between 15-27°C (59-81°F).
The optimum temperature of operation is between 18-21°C (65-70°F).